|
KMID : 1140120080130040284
|
|
Cancer Prevention Research
2008 Volume.13 No. 4 p.284 ~ p.291
|
|
|
|
|
|
|
|
Abstract
|
|
|
|
Anticancer effects of soluble and non-soluble chitosans were studied in HT-29 human colon cancer cells. Soluble chitosan S-10 (SC) inhibited 88% of the proliferation at 5 mg/ml. Non-soluble chitosan NS-8 (NSC) showed 83% anticancer effects at 1 mg/ml on the growth of the HT-29 cells. SC and NSC inhibited the growth of cells in a time-dependent manner. Chitosans induced apoptosis in the HT-29 cells and it was associated with the increase of Bax, p53, p21 and decrease of Bcl-2. The level of cIAP-1 mRNA expression decreased in NSC. These results suggest that S-10 (DA 90%, vis 5 cps) and NS-8 (DA 95%, vis 22 cps) chitosans especially showed high anticancer effects in the colon cancer cells.
|
|
|
KEYWORD
|
|
|
Soluble/non-soluble chitosan, Anticancer, Apoptosis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|